The 2025 NFL season is starting to come into view, which means more NFL player props are being released with each passing week. I previously broke down the 2025 NFL Rushing Yards Props, and it’s time to dive into the 2025 NFL Most Rushing Yards Odds for the top running backs and quarterbacks. In this article, I highlighted bets I’ve already made on Ashton Jeanty and a few additional wagers I considered.
Saquon Barkley cashed the third-shortest odds at +700 with an NFL-best 2005 rushing yards last season. He bested Derrick Henry (1921, +1000) despite resting in the season finale, and no other RB cleared 1500+ rushing yards. Saquon is the favorite to repeat as the league leader in receiving yards entering his age-28 season at +300 odds. He’s followed by Henry (+550), Jonathan Taylor (+1000), Christian McCaffrey (+1200), and Bijan Robinson (+1300) at 13/1 odds or shorter.
Check out all of my 2025 NFL Futures articles during the off-season and my Best Bets for the 2025 season. We finished up +59.83 units for the 2024 season, including +23.93 units on Futures wagers.
Rushing Yards Leaders From the Last Decade
| Year | Running Back | Age | Rushing Yards | Odds (rank) |
| 2024 | Saquon Barkley (Phi) | 27 | 2005 | +700 (3rd) |
| 2023 | Christian McCaffrey (SF) | 27 | 1459 | +3000 (10th) |
| 2022 | Josh Jacobs (LV) | 24 | 1653 | +4000 (20th) |
| 2021 | Jonathan Taylor (Ind) | 22 | 1811 | +900 (4th) |
| 2020 | Derrick Henry (Ten) | 26 | 2027 | +600 (1st) |
| 2019 | Derrick Henry (Ten) | 25 | 1540 | +1300 (3rd) |
| 2018 | Ezekiel Elliott (Dal) | 23 | 1434 | +285 (1st) |
| 2017 | Kareem Hunt (KC) | 22 | 1327 | +20000 (32nd) |
| 2016 | Ezekiel Elliott (Dal) | 21 | 1631 | +850 (3rd) |
| 2015 | Adrian Peterson (Min) | 30 | 1485 | +500 (1st) |
Historical Hints
Saquon Barkley (+700) ended a two-year run of longer-shot winners in this category. Josh Jacobs (+4000) and Christian McCaffrey (+3000) came from deeper in the pack to lead the league in rushing yards in 2022 and 2023, respectively. Backs ranked in the top four in odds have taken home the honor seven times in the last decade. Kareem Hunt (+20000) is one player who came from out of nowhere to lead the league as a third-round pick in 2017.
Barkley joined the 2000-yard club with Derrick Henry (+600), who did it during the 2020 season. The league leader in rushing yards fell below the 100 YPG pace for three straight years in 2017-19. Henry and Jonathan Taylor (+900) blew past the century mark in 2020-21, while Jacobs (97.2 rushing YPG) and CMC (85.8) fell below the century mark per game standard in 2022-23. It comes as no surprise that the rushing yards leader has checked in at 27 years old or younger in nine straight seasons. Adrian Peterson (+500) was the last “older” back to win the rushing crown at 30 years old.
2025 NFL Most Rushing Yards Odds
The table is sorted by Fantasy Points rushing yards projection. You should target the Longest Odds for Most Rushing Yards to maximize your potential return. I used odds from DraftKings (DK), FanDuel (FD), Caesars (CZR), ESPN Bet (ESPN), and Bet365 (365) as of June 23.
| Runner | FP Projection | Longest Odds | Shortest Odds |
| Saquon Barkley (Phi) | 1632.9 | +300 (ESPN) | +230 (CZR) |
| Derrick Henry (Bal) | 1590.5 | +550 (FD) | +400 (multiple) |
| Ashton Jeanty (LV) | 1315.7 | +2000 (ESPN) | +1500 (365) |
| Bijan Robinson (Atl) | 1303.2 | +1300 (FD) | +1000 (multiple) |
| Jonathan Taylor (Ind) | 1219.5 | +1000 (multiple) | +750 (CZR) |
| Jahmry Gibbs (Det) | 1190.4 | +2000 (CZR/365) | +1400 (DK) |
| Bucky Irving (TB) | 1181.1 | +2500 (CZR) | +1400 (365) |
| Kyren Williams (LAR) | 1178.5 | +2500 (DK) | +2000 (CZR/ESPN) |
| Josh Jacobs (LV) | 1114.9 | +2100 (FD) | +1600 (365) |
| James Cook (Buf) | 1043.0 | +7500 (CZR) | +3000 (FD) |
| James Conner (Ari) | 1021.3 | +5000 (DK) | +3500 (CZR/ESPN) |
| Breece Hall (NYJ) | 1012.6 | +4000 (CZR/ESPN) | +2800 (365) |
| Chase Brown (Cin) | 996.2 | +7500 (CZR) | +3700 (FD) |
| Kaleb Johnson (Pit) | 991.7 | +10000 (FD) | +7500 (multiple) |
| Tony Pollard (Ten) | 989.3 | +10000 (DK/365) | +5000 (FD) |
| Chuba Hubbard (Car) | 987.8 | +3000 (DK) | +2500 (CZR/ESPN) |
| Runner | FP Projection | Longest Odds | Shortest Odds |
| Christian McCaffrey (SF) | 983.6 | +1200 (FD) | +750 (CZR) |
| Omarion Hampton (LAC) | 970.4 | +5000 (multiple) | +4000 (365) |
| Quinshon Judkins (Cle) | 936.9 | +8000 (CZR) | +6000 (365) |
| Kenneth Walker (Sea) | 928.5 | +7500 (CZR/ESPN) | +4100 (FD) |
| De’Von Achane (Mia) | 890.4 | +5000 (CZR) | +3300 (FD) |
| Joe Mixon (Hou) | 870.0 | +5000 (DK) | +3500 (365) |
| Aaron Jones (Min) | 863.3 | +8000 (DK) | +5000 (multiple) |
| TreVeyon Henderson (NE) | 833.7 | +10000 (DK/ESPN) | +7500 (365) |
| Alvin Kamara (NO) | 827.7 | +10000 (FD) | +4000 (ESPN) |
| Bhaysul Tuten (Jax) | 818.4 | +30000 (365) | +10000 (DK) |
| D’Andre Swift (Chi) | 815.6 | +8000 (DK) | +4500 (FD) |
| R.J. Harvey (Den) | 784.8 | +6500 (DK) | +4000 (CZR) |
| David Montgomery (Det) | 781.4 | +12000 (FD) | +5000 (CZR) |
| Brian Robinson (Was) | 778.3 | +10000 (DK/365) | +7500 (CZR/ESPN) |
| Isiah Pacheco (KC) | 760.5 | +10000 (DK/365) | +6500 (FD) |
| Tyrone Tracy (NYG) | 730.4 | +6500 (DK) | +4000 (FD) |
Brolley’s Best Bets
Ashton Jeanty (LV) most regular season rushing yards (+2000, ESPNBet).
A rookie hasn’t led the league since Ezekiel Elliott and Kareem Hunt accomplished the feat in back-to-back seasons in 2016-17. The Raiders spent top-6 draft capital to select Jeanty to be their new bell-cow back after he led the FBS in rushing attempts (374) and rushing yards (2601) last season. Jeanty is the clear lead runner in Las Vegas, and his only competition for touches comes from a 33-year-old Raheem Mostert, Sincere McCormick, and Zamir White. Jeanty’s workload should rank among the league’s best for the position. We’re projecting him for the third-highest carry share (72%), the fourth-most carries (276.8), and the third-most rushing yards (1315.7). Jeanty needs Las Vegas’ offense to take a major step forward if he wants to be a serious contender. The acquisition of Geno Smith and the hires of Pete Carroll and Chip Kelly give me hope that this offense can at least be a league-average unit.
Las Vegas’ offensive line will need to perform better after ranking 29th in adjusted YBC/ATT (1.55) and 31st in success rate (40.8%), but Jeanty will help Las Vegas’ O-line perform better. Kelly’s offenses in Philadelphia (2013-15) and San Francisco (2016) each ranked in the top 14 in rushing yards, including a first-place finish in 2013 and a fourth-place finish in 2016. My biggest concern is that the Raiders will face more negative game scripts than most teams, with a projected win total of 6.5. It can be done as Josh Jacobs showed in 2022 when he led the league with 1653 yards on a six-win Raiders team. Jeanty owns the sixth-best odds to win the rushing crown, and we’re getting slightly longer odds because he’s a rookie.
Brolley’s Leans
Saquon Barkley (Phi) most regular season rushing yards (+300, FanDuel)
Barkley is the deserving favorite to defend his rushing title after becoming the first player to run for 2000+ yards since Derrick Henry accomplished the feat in 2020. Sportsbooks aren’t giving us any discounts for him to do it again in 2025. He led the league in attempts (345), rushing YPG (125.3), and rushing yards (2005) despite sitting out the season finale. Barkley led the league in YBCO/ATT (3.55) and explosive yards (835) behind the league’s best offensive line, and our Scott DiBenedetto ranked Philadelphia as the top offensive line for this season. His only area of concern is at RG with Tyler Steen projected to take over for Mekhi Becton (Chargers).
Barkley figures to be the centerpiece of one of the league’s best offenses once again after the Eagles ranked 31st in pass rate over expectation (-6.1%). He previously had some issues staying on the field from 2019-21 in New York, but has racked up 996 carries over the last three years (postseason included). The favorite for the rushing crown has been at 4/1 odds or shorter for four straight years — Christian McCaffrey (2024), Nick Chubb (2023), Jonathan Taylor (2022), and Derrick Henry (2021) — and each has come up short of winning the title. The odds simply aren’t long enough to wager on Barkley, and they’d need to get north of +400 for me to consider betting on him.
Jahmyr Gibbs (Det) most regular season rushing yards (+2000, Caesars)
Gibbs showed in the final three regular-season games that he’d be right with Saquon Barkley and Derrick Henry as a top-three favorite for the rushing crown if David Montgomery were out of the mix. With Monty nursing a knee injury in Weeks 16-18, Gibbs exploded for 64/365/5 rushing against the Bears, 49ers, and Vikings. His carry share and carries per game went from 42.5% and 13.3 with Monty to 66.7% and 21.3 in three games without Monty. Montgomery is back in the mix, which will limit Gibbs’ weekly carries more than the rest of the top favorites. Gibbs’ carry share (46.8%) paled in comparison to Barkley (57.9%), Henry (58.7%), Jonathan Taylor (73.7%), Christian McCaffrey (54.3%), and Bijan Robinson (61.4%).
Gibbs ranked first in explosive run rate (10.0%), third in stuff rate (37.2%), and fifth in MTF/ATT (.23), which propelled him to the fifth-most rushing yards (1412). Our Scott DiBenedetto ranked Detroit as the fifth-best offensive line, but there is more concern about the group than last season. Frank Ragnow retired, and Kevin Zeitler signed with the Titans, and their replacements, Tate Ratledge and Christian Mahogany, are unproven heading into the season. Detroit will also be breaking in a new playcaller, with John Morton replacing Ben Johnson, who led a top-5 offense the last three years. I strongly considered betting Gibbs at his 20/1 odds, but my small concerns about his carry share, Detroit’s O-line, and the playcalling have me shying away from the wager.
James Cook (Buf) most regular season rushing yards (+7500, Caesars)
James Cook is currently set to make $5.7 million in 2025 and is seeking a contract extension entering the final year of his rookie deal. He’s coming off a career-high 16 rushing TDs and owns a career 4.9 YPC average, but he’s averaged 13.5 carries per game the last two seasons. Cook is seeking an annual average salary of $15 million per year, which would tie him with Derrick Henry as the third-highest paid RB behind Saquon Barkley ($20.6M) and Christian McCaffrey ($19M) in AAV. He’ll have to lower his asking price after leading a three-man committee last season, which involved Ray Davis and Ty Johnson. He ranked 38th in snap share (48%) and 28th in carry share (45.2%) among RBs last season.
Cook ranked seventh in YPC (4.87), eighth in explosive yards (313), and seventh in YBCO/ATT (2.39) behind one of the league’s better O-lines. Our Scott DiBenedetto ranked Buffalo as the sixth-best offensive line entering 2025, and they return the same starting group, which is led by one of the NFL’s better tackle duos in Dion Dawkins and Spencer Brown. I can’t quite get to the window even at these extra-long odds, but he’s an intriguing long shot if he could get to a 60% carry share or better by a coach’s decision or a Davis injury.
Kenneth Walker (Sea) most regular season rushing yards (+7500, ESPN Bet)
Walker is my favorite long-shot bet in this market despite his rushing yards dipping in each of his first three seasons (573<905<1050). He’s been one of the best backs after contact, ranking 10th YACO/ATT (2.65) and first in MTF/ATT (.30) last season. The problem was that he ranked ahead of only Antonio Gibson in YBCO/ATT (1.09) among 46 RBs with 100+ carries. Seattle’s offensive line ranked 28th in adjusted YBC/ATT (1.56) and 28th in success rate (45.2%) in Ryan Grubb’s only season as playcaller. Our Scott DiBenedetto isn’t too optimistic for a turnaround despite the unit undergoing a significant overhaul. He ranked Seattle as the third-worst offensive line, but they at least spent the 18th overall pick on Grey Zabel, who could help this running game move in the right direction.
Mike Macdonald hired Klint Kubiak to call plays, who said at his initial press conference that it was important to focus on the run game and that he was excited to see Walker in his zone scheme. Our Ryan Heath wrote, “Walker averages 4.54 career YPC on outside zone, reflecting a ~13% efficiency boost compared to all other carries. In contrast, Zach Charbonnet has averaged just 3.67 career YPC on outside zone, ~21% less than his average on other carries.” Walker ranked sixth in carry share (62.4%) even with Charbonnet nipping at his heels last season. Two coaching staffs have given Walker major workloads, and he’s talented enough to break out for a monster season if he gets enough running room up front.
