| Coaches | |
|---|---|
| Position | Name |
| Head Coach | Kyle Shanahan |
| Offensive Coordinator | Klay Kubiak |
| Defensive Coordinator | Robert Saleh |
| Special Teams Coach | Brant Boyer |
| Offense | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | NO | Player 4 | NO | Player 5 |
| QB | 13 | Brock Purdy | 10 | Mac Jones | NA | Kurtis Rourke(R) | 14 | Tanner Mordecai | ||
| RB | 23 | Christian McCaffrey | 31 | Isaac Guerendo | NA | Jordan James(R) | 32 | Patrick Taylor | 20 | Israel Abanikanda |
| LWR | 11 | Brandon Aiyuk | NA | Demarcus Robinson | 84 | Russell Gage | 87 | Isaiah Hodgins | ||
| SWR | 15 | Jauan Jennings | 19 | Jacob Cowing | 81 | Trent Taylor | NA | Junior Bergen(R) | ||
| RWR | 1 | Ricky Pearsall | NA | Jordan Watkins(R) | 83 | Terique Owens | NA | Isaiah Neyor(R) | ||
| TE | 85 | George Kittle | NA | Luke Farrell | 9 | Brayden Willis | 88 | Jake Tonges | 89 | Mason Pline |
| FB | 44 | Kyle Juszczyk | ||||||||
| LT | 71 | Trent Williams | 62 | Austen Pleasants | 76 | Jalen McKenzie | 67 | Isaac Alarcon | ||
| LG | 78 | Ben Bartch | 63 | Nick Zakelj | NA | Zack Johnson | ||||
| C | 64 | Jake Brendel | 61 | Matt Hennessy | 66 | Drake Nugent | ||||
| RG | 77 | Dominick Puni | NA | Connor Colby(R) | NA | Drew Moss(R) | ||||
| RT | 68 | Colton McKivitz | 74 | Spencer Burford | 60 | Sebastian Gutierrez | ||||
| Defense | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | NO | Player 4 | NO | Player 5 |
| LDE | 97 | Nick Bosa | 94 | Yetur Gross-Matos | 95 | Drake Jackson | 96 | Jonathan Garvin | 59 | Tarron Jackson |
| RDE | NA | Mykel Williams(R) | 91 | Sam Okuayinonu | 51 | Robert Beal Jr. | 58 | Alex Barrett | ||
| LDT | 92 | Jordan Elliott | NA | CJ West(R) | 93 | Kalia Davis | ||||
| RDT | 90 | Kevin Givens | NA | Alfred Collins(R) | 69 | Evan Anderson | NA | Sebastian Valdez(R) | ||
| WLB | 53 | Dee Winters | 57 | Luke Gifford | 47 | DaShaun White | ||||
| MLB | 54 | Fred Warner | 48 | Tatum Bethune | NA | Stone Blanton(R) | ||||
| SLB | NA | Nick Martin(R) | 41 | Jalen Graham | 36 | Curtis Robinson | ||||
| LCB | 22 | Tre Brown | 36 | Tre Avery | NA | Tre Tomlinson | NA | Jakob Robinson(R) | ||
| RCB | NA | Renardo Green | 28 | Darrell Luter Jr. | 26 | Chase Lucas | ||||
| SS | 27 | Ji'Ayir Brown | NA | Richie Grant | 30 | George Odum | NA | Quindell Johnson | ||
| FS | 6 | Malik Mustapha | NA | Jason Pinnock | NA | Marques Sigle(R) | 38 | Jaylen Mahoney | ||
| NB | 2 | Deommodore Lenoir | NA | Upton Stout(R) | NA | Siran Neal | ||||
| Special Teams | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | ||||
| P | 3 | Mitch Wishnowsky | ||||||||
| K | 4 | Jake Moody | ||||||||
| LS | 46 | Jon Weeks | ||||||||
| PR | 19 | Jacob Cowing | 1 | Ricky Pearsall | ||||||
| KR | 32 | Patrick Taylor | 31 | Isaac Guerendo | ||||||
| H | 3 | Mitch Wishnowsky | ||||||||
| KO | 4 | Jake Moody | ||||||||
