| Coaches | |
|---|---|
| Position | Name |
| Head Coach | Jim Harbaugh |
| Offensive Coordinator | Greg Roman |
| Defensive Coordinator | Jesse Minter |
| Special Teams Coach | Ryan Ficken |
| Offense | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | NO | Player 4 | NO | Player 5 |
| QB | 10 | Justin Herbert | 4 | Taylor Heinicke | 5 | Trey Lance | NA | DJ Uiagalelei(R) | ||
| RB | NA | Omarion Hampton(R) | 22 | Najee Harris | 28 | Hassan Haskins | 30 | Kimani Vidal | 34 | Jaret Patterson |
| LWR | 81 | Mike Williams | 1 | Quentin Johnston | 82 | Brenden Rice | 41 | Dez Fitzpatrick | ||
| SWR | 15 | Ladd McConkey | 12 | Derius Davis | 39 | Jaylen Johnson | NA | Luke Grimm(R) | ||
| RWR | NA | Tre Harris(R) | NA | KeAndre Lambert-Smith(R) | 88 | Jalen Reagor | ||||
| TE | 89 | Will Dissly | 83 | Tyler Conklin | NA | Oronde Gadsden II(R) | 42 | Tucker Fisk | 49 | Jordan Petaia(R) |
| FB | 44 | Scott Matlock | ||||||||
| LT | 70 | Rashawn Slater | NA | Branson Taylor(R) | NA | Corey Stewart(R) | ||||
| LG | 77 | Zion Johnson | 61 | Karsen Barnhart | NA | Nash Jones(R) | ||||
| C | 75 | Bradley Bozeman | 78 | Andre James | NA | Josh Kaltenberger(R) | ||||
| RG | 73 | Mekhi Becton | 68 | Jamaree Salyer | 60 | Bucky Williams | ||||
| RT | 76 | Joe Alt | 79 | Trey Pipkins | 74 | Tyler McLellan | NA | Savion Washington(R) | ||
| Defense | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | NO | Player 4 | NO | Player 5 |
| DE | 91 | Da'Shawn Hand | 92 | Justin Eboigbe | 44 | Scott Matlock | ||||
| DT | 93 | Otito Ogbonnia | 96 | Naquan Jones | 98 | Christopher Hinton | NA | Josh Fuga(R) | ||
| NT | 90 | Teair Tart | NA | Jamaree Caldwell(R) | NA | TeRah Edwards(R) | ||||
| LOLB | 45 | Tuli Tuipulotu | NA | Kyle Kennard(R) | 50 | Caleb Murphy | 56 | Chris Collins | NA | Kylan Guidry(R) |
| LILB | NA | Daiyan Henley | 43 | Troy Dye | 51 | Jeremiah Jean-Baptiste | NA | Marlowe Wax(R) | ||
| RILB | 25 | Junior Colson | 6 | Denzel Perryman | 53 | Del'Shawn Phillips | ||||
| ROLB | 52 | Khalil Mack | 48 | Bud Dupree | 57 | Tre'Mon Morris-Brash | NA | Garmon Randolph(R) | ||
| LCB | 26 | Donte Jackson | 33 | Deane Leonard | NA | Trikweze Bridges(R) | NA | Jordan Oladokun(R) | ||
| RCB | 20 | Cam Hart | 24 | Benjamin St-Juste | NA | Nikko Reed(R) | NA | Eric Rogers(R) | ||
| SS | 3 | Derwin James | 23 | Tony Jefferson | NA | R.J. Mickens(R) | NA | Jaylen Jones(R) | ||
| FS | 32 | Alohi Gilman | 2 | Elijah Molden | 40 | Kendall Williamson | 38 | Emany Johnson | ||
| NB | 29 | Tarheeb Still | 36 | Ja'Sir Taylor | NA | Myles Purchase(R) | ||||
| Special Teams | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | ||||
| P | 16 | J.K. Scott | ||||||||
| K | 11 | Cameron Dicker | ||||||||
| LS | 47 | Josh Harris | ||||||||
| PR | 12 | Derius Davis | 15 | Ladd McConkey | 88 | Jalen Reagor | NA | Luke Grimm(R) | ||
| KR | 12 | Derius Davis | 28 | Hassan Haskins | 88 | Jalen Reagor | NA | Luke Grimm(R) | ||
| H | 16 | J.K. Scott | ||||||||
| KO | 11 | Cameron Dicker | ||||||||
